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human α2 macroglobulin  (Athens Research)


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    Athens Research human α2 macroglobulin
    Human α2 Macroglobulin, supplied by Athens Research, used in various techniques. Bioz Stars score: 91/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+%CE%B12+macroglobulin/Alpha+2+Macrglobulin/pmc04281766-220-14-19
    Average 91 stars, based on 2 article reviews
    human α2 macroglobulin - by Bioz Stars, 2026-10
    91/100 stars

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    Clinical Proteomics:

    Article Title: Miropin, a Novel Bacterial Serpin from the Periodontopathogen Tannerella forsythiaInhibits a Broad Range of Proteases by Using Different Peptide Bonds within the Reactive Center Loop
    Article Snippet: .. The following enzymes and reagents were used: human neutrophil elastase, cathepsin G, ecotin, and human α2-macroglobulin (BioCentrum, Krakow, Poland; Athens Research and Technology, Athens, GA); porcine pancreatic elastase (Promega, Fitchburg, WI); bovine pancreatic α-chymotrypsin, bovine pancreatic trypsin, thrombin from human plasma, subtilisin Carlsberg, benzoyl-Arg-pNA, 2 Boc-Val-Pro-Arg-aminofluoromethylcoumarin, Boc-Gln-Ala-Arg-7-amino-4-methylcoumarin (AMC), and metoxysuccinyl-Ala-Ala-Pro-Val-pNA (Sigma); succinyl-Ala-Ala-Pro-Phe-pNA and 7-methoxycoumarin-4-acetic acid (MCA)-FVT-4-guanidine-phenylalanine (Gnf)-SW-Anb-NH 2 (Anb is the amide of amino benzoic acid; Merck). .. Three molecular weight markers were used: PageRuler Unstained Low Range Protein Ladder (size range: 3.4–100 kDa), PageRuler Prestained Protein Ladder (size range: 20–75 kDa) from Thermo Scientific Fermentas (Vilnius, Lithuania), and Precision Plus Protein Kaleidoscope (size range: 10–250 kDa) from Bio-Rad.

    Article Title: Miropin, a Novel Bacterial Serpin from the Periodontopathogen Tannerella forsythiaInhibits a Broad Range of Proteases by Using Different Peptide Bonds within the Reactive Center Loop
    Article Snippet: .. Enzymes, Inhibitors, Substrates, and Other Reagents The following enzymes and reagents were used: human neutrophil elastase, cathepsin G, ecotin, and human α2-macroglobulin (BioCentrum, Krakow, Poland; Athens Research and Technology, Athens, GA); porcine pancreatic elastase (Promega, Fitchburg, WI); bovine pancreatic α-chymotrypsin, bovine pancreatic trypsin, thrombin from human plasma, subtilisin Carlsberg, benzoyl-Arg-pNA, 2 Boc-Val-Pro-Arg-aminofluoromethylcoumarin, Boc-Gln-Ala-Arg-7-amino-4-methylcoumarin (AMC), and metoxysuccinyl-Ala-Ala-Pro-Val-pNA (Sigma); succinyl-Ala-Ala-Pro-Phe-pNA and 7-methoxycoumarin-4-acetic acid (MCA)-FVT-4-guanidine-phenylalanine (Gnf)-SW-Anb-NH 2 (Anb is the amide of amino benzoic acid; Merck). .. Three molecular weight markers were used: PageRuler Unstained Low Range Protein Ladder (size range: 3.4–100 kDa), PageRuler Prestained Protein Ladder (size range: 20–75 kDa) from Thermo Scientific Fermentas (Vilnius, Lithuania), and Precision Plus Protein Kaleidoscope (size range: 10–250 kDa) from Bio-Rad.



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    Image Search Results


    Inhibitors and cofactors of the common and Protein C pathways in SARS‐CoV‐2 infection and controls. (A) Antithrombin, (B) TAT, Thrombin‐Antithrombin complex, (C) Heparin Cofactor II, (D) Protease Nexin‐1, (E) α2‐macroglobulin, (F) Protein Z, (G) Protein Z Inhibitor, (H) Protein C, (I) Protein S (total), and (J) Protein C Inhibitor plasma concentrations were determined by ELISA in controls and COVID‐19 patients. Each symbol corresponds to one patient. Means and SEM are indicated. NS, non‐significant; * p ≤ 0.05; **** p ≤ 0.0001 (Kruskal‐Wallis test, or Mann‐Whitney U test).

    Journal: EJHaem

    Article Title: SARS‐CoV‐2 infection results in upregulation of Plasminogen Activator Inhibitor‐1 and Neuroserpin in the lungs, and an increase in fibrinolysis inhibitors associated with disease severity

    doi: 10.1002/jha2.654

    Figure Lengend Snippet: Inhibitors and cofactors of the common and Protein C pathways in SARS‐CoV‐2 infection and controls. (A) Antithrombin, (B) TAT, Thrombin‐Antithrombin complex, (C) Heparin Cofactor II, (D) Protease Nexin‐1, (E) α2‐macroglobulin, (F) Protein Z, (G) Protein Z Inhibitor, (H) Protein C, (I) Protein S (total), and (J) Protein C Inhibitor plasma concentrations were determined by ELISA in controls and COVID‐19 patients. Each symbol corresponds to one patient. Means and SEM are indicated. NS, non‐significant; * p ≤ 0.05; **** p ≤ 0.0001 (Kruskal‐Wallis test, or Mann‐Whitney U test).

    Article Snippet: DUOSet enzyme‐linked immunosorbent assay (ELISA) performed for Kallistatin (SERPINA4, DY1669), Plasminogen Activator Inhibitor‐1 (PAI‐1, SERPINE1; DY1786), Protein Z Inhibitor (PZI, SERPINA10; DY8115), α2‐Macroglobulin (A2M; DY1938), Protease Nexin‐2/Amyloid Beta Precursor Protein (PN2/AβPP; DY850) and C1‐Inhibitor (C1‐INH, SERPING1; DY2488) from Bio‐Techne/R&D (Minneapolis, MN).

    Techniques: Infection, Enzyme-linked Immunosorbent Assay, MANN-WHITNEY

    Univariate logistic regression of association of covariates with moderate and severe diseases

    Journal: EJHaem

    Article Title: SARS‐CoV‐2 infection results in upregulation of Plasminogen Activator Inhibitor‐1 and Neuroserpin in the lungs, and an increase in fibrinolysis inhibitors associated with disease severity

    doi: 10.1002/jha2.654

    Figure Lengend Snippet: Univariate logistic regression of association of covariates with moderate and severe diseases

    Article Snippet: DUOSet enzyme‐linked immunosorbent assay (ELISA) performed for Kallistatin (SERPINA4, DY1669), Plasminogen Activator Inhibitor‐1 (PAI‐1, SERPINE1; DY1786), Protein Z Inhibitor (PZI, SERPINA10; DY8115), α2‐Macroglobulin (A2M; DY1938), Protease Nexin‐2/Amyloid Beta Precursor Protein (PN2/AβPP; DY850) and C1‐Inhibitor (C1‐INH, SERPING1; DY2488) from Bio‐Techne/R&D (Minneapolis, MN).

    Techniques: